Deleted in lymphocytic leukemia 2 like (DLEU2L)

Deleted in lymphocytic leukemia 2 like (DLEU2L) is a long non-coding RNA gene located on chromosome 1p31.3, also known as BCMSUN. DLEU2L is functionally characterized as a competitive endogenous RNA (ceRNA), acting to suppress tumor progression by sponging oncogenic microRNAs such as miR-210-3p. This interaction upregulates tumor suppressor genes like BRCA2, contributing to DNA damage repair and inhibiting proliferation and metastasis in cancers such as pancreatic cancer. DLEU2L is affiliated with hematological malignancies and solid tumors, and its altered expression can influence cancer outcomes, making it a potential therapeutic target and biomarker. Research on DLEU2L’s detailed molecular mechanisms and clinical applications is at an early stage, with ongoing efforts to delineate transcript-specific and interaction-driven safety profiles.

Other names

BCMSUN

Acts as a decoy (ceRNA) for miR-210-3p, reducing its availability to target genes such as BRCA2, thereby upregulating BRCA2 expression and enhancing DNA repair capacity. Suppresses oncogenic features by downregulating miR-210-3p, inhibits proliferation, migration, and invasion, and promotes apoptosis in cancer cells.