Deleted in malignant brain tumors 1 protein (DMBT1)

Deleted in malignant brain tumors 1 protein (DMBT1) is a large, multidomain, secreted glycoprotein that is widely expressed at epithelial barriers such as the respiratory tract, gut, and salivary glands[1][2][5][6]. It is a member of the scavenger receptor cysteine-rich (SRCR) superfamily and contains multiple SRCR domains, interspersed with glycosylated regions, as well as CUB and zona pellucida-type domains[1][2][3][5]. DMBT1 acts as a pattern recognition molecule, binding a broad array of pathogens (bacterial and viral), and mediates aggregation and clearance of microbes, providing an important component of mucosal innate immunity[5]. It also binds host immune proteins, including IgA, surfactant proteins, and lactoferrin, modulating immune defense at mucosal surfaces[5]. In addition, DMBT1 is involved in epithelial cell differentiation, polarity, and possibly tissue regeneration; its deletion or downregulation is linked to multiple cancers, where it is believed to contribute to tumor immune surveillance and normal tissue architecture[3][6]. DMBT1 is not currently considered a direct therapeutic target, but its altered expression or mutations serve as biomarkers in certain cancers. No drugs are known to directly target DMBT1.

Other names

Scavenger receptor cysteine-rich domain-containing protein DMBT1glycoprotein 340GP340Gp-340SAGSALSAHensinSalivary agglutininSalivary scavenger and agglutininSurfactant pulmonary-associated D-binding proteinvomeroglandinmuclinCRP-ductinEbnerinapactinpancrinbovine gall bladder mucin

not applicable (no approved drugs directly targeting DMBT1)