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Target intelligence / Profile preview
Deleted in primary ciliary dyskinesia homolog (DPCD)
- Target
- DPCD
- Molecular classification
- Carrier protein, Other (structural/assembly cofactor)
01
Overview
Deleted in primary ciliary dyskinesia homolog (DPCD) is a protein crucial for the formation and maintenance of cilia, the hair-like organelles present on certain cell types. The absence or mutation of DPCD results in primary ciliary dyskinesia, a rare genetic disorder characterized by defective ciliated cell function, leading to mucociliary clearance issues and chronic respiratory disease. DPCD interacts with RUVBL1 and RUVBL2 (AAA+ ATPases), suggesting a role in assembly or regulation of macromolecular complexes essential for cilia biogenesis. DPCD is considered a structural or cofactor protein, not a conventional drug target, and no drugs, mechanisms, or biomarker uses are associated with it[1][4][5].
- Other names
- Protein DPCDDPCDDKFZP566F084RP11-529I10.4deleted in a mouse model of primary ciliary dyskinesia
02
Mechanism of action
None
03
Biological functions
Cilia formationMaintenance of ciliated cellsMay act as a protein partner in large macromolecular assemblies with AAA+ ATPases (RUVBL1/RUVBL2)
04
Disease associations
Primary ciliary dyskinesia (causal gene when deleted/disrupted)No established roles in cancer, inflammation, or neurodegeneration
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