Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1)

Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1) is an enzyme encoded by the human ECH1 gene that catalyzes the isomerization of 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA as part of the auxiliary pathway of fatty acid β-oxidation[1][3][9]. It belongs to the hydratase/isomerase superfamily, localizes primarily to peroxisomes and mitochondria, and helps metabolize unsaturated fatty acids with conjugated double bonds[3]. Altered expression or function of ECH1 has been implicated in metabolic conditions such as adrenoleukodystrophy, steatohepatitis, and myocardial infarction[1][4][7]. The gene product may serve as a biomarker for hepatic disease but is not currently a direct drug target.

Other names

Enoyl-CoA hydratase 1Delta(3,5)-Delta(2,4)-dienoyl-coenzyme A isomerasePeroxisomal enoyl-CoA hydratase 1Dienoyl-CoA isomeraseHPXELEpididymis secretory sperm binding protein

Not specifically applicable, as ECH1 is not currently a direct drug target. Drugs affecting fatty acid oxidation or peroxisome proliferators may affect ECH1 activity indirectly[4][1].