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Delta-13-prostaglandin reductase
- Molecular classification
- Enzyme, Oxidoreductase, Medium-chain dehydrogenase/reductase superfamily
01
Overview
Delta-13-prostaglandin reductase (also known as 15-oxoprostaglandin Δ13-reductase) is an enzyme involved in the catabolism of prostaglandins, specifically catalyzing the reduction of the double bond at the 13-14 position of 15-ketoprostaglandins. This reaction is a key step in the metabolic inactivation of pro- and anti-inflammatory eicosanoids. It plays a critical role in regulating adipogenesis via modulation of PPARγ activity. The enzyme utilizes NADPH as a cofactor and belongs to the medium-chain dehydrogenase/reductase superfamily. Inhibition or modulation may affect insulin sensitivity or adipogenesis, making it a potential therapeutic target in metabolic diseases.
- Other names
- 15-oxoprostaglandin Δ13-reductase
02
Mechanism of action
Reduction of the C13-C14 double bond in 15-ketoprostaglandins using NADPH as a cofactor, leading to inactivation of prostaglandins.
03
Biological functions
Eicosanoid catabolismProstaglandin inactivationRegulation of adipogenesisModulation of PPARγ activity
04
Disease associations
ObesityMetabolic disordersInflammation
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