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Fatty Acid Desaturase 1 (None)
- Target
- None
- Molecular classification
- Enzyme, Fatty Acid Desaturase
01
Overview
Fatty acid desaturase 1 (FADS1), also known as delta-5 desaturase (D5D), is an enzyme encoded by the *FADS1* gene. It plays a critical role in lipid metabolism by introducing double bonds into fatty acyl chains, thereby regulating the degree of unsaturation of fatty acids. It is crucial for synthesizing long-chain PUFAs such as arachidonic acid (ARA) and eicosapentaenoic acid (EPA), which are vital components of cell membranes and serve as precursors for various bioactive lipid mediators. Altered expression or genetic polymorphisms in *FADS1* are associated with metabolic phenotypes and cancer.
- Other names
- D5DFADSD5LLCDL1TU12Delta-5 Desaturase
02
Mechanism of action
Catalyzes the introduction of a double bond at the delta-5 position of polyunsaturated fatty acids (PUFAs)
03
Biological functions
Lipid metabolismFatty acid desaturationSynthesis of long-chain polyunsaturated fatty acids (LC-PUFAs)Precursor production for signaling lipidsRegulation of membrane fluidity
04
Disease associations
Metabolic diseasesCancerInflammation
05
Safety considerations
Altered PUFA ratiosImpact on membrane protein functionPotential effects on inflammatory responses
06
Biomarkers
FADS1 expression levels in tumorsGenetic variants within the FADS gene cluster
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