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Target intelligence / Profile preview
Delta-like 1 homolog (DLK1)
- Target
- DLK1
- Molecular classification
- Single-pass transmembrane glycoprotein, EGF-like protein, Notch ligand family
01
Overview
Delta-like 1 homolog (DLK1) is a transmembrane protein and member of the Notch/Delta/Serrate family. It regulates cell growth, inhibits adipogenesis, and plays complex roles in muscle development and regeneration. DLK1 is overexpressed in various tumors and is paternally expressed. Cleavage by ADAM17/TACE releases a soluble form that is active in inhibiting adipogenesis.
- Other names
- DLKDLK-1Delta1FA1Fetal Antigen 1PREF1Preadipocyte Factor 1Pref-1ZOGpG2AW742678DlkILy107Peg9SCP1
02
Mechanism of action
ADAM17/TACE-mediated cleavage releasing soluble form; Non-canonical Notch signaling modulation
03
Biological functions
Regulation of cell growthInhibition of adipogenesisRegulation of muscle developmentRegulation of muscle regenerationEpigenetic regulationCell fate determination
04
Disease associations
CancerSkeletal muscle disorders
05
Safety considerations
Potential for off-target effects due to EGF-like repeatsComplex role in muscle regeneration requires careful modulation
06
Biomarkers
DLK1 expression levels in tumor tissuesDLK1 expression levels in serum
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