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Target intelligence / Profile preview
Delta-like Ligand 3 Protein (DLL3)
- Target
- DLL3
- Molecular classification
- Transmembrane protein, Notch ligand family, Developmental protein
01
Overview
Delta-like ligand 3 (DLL3) is a transmembrane protein and a member of the Notch ligand family. Unlike other Notch ligands, DLL3 primarily acts as an inhibitor of Notch signaling within the same cell. It is highly expressed during fetal development and is often overexpressed in high-grade neuroendocrine tumors, making it a therapeutic target. Loss-of-function mutations cause spondylocostal dysostosis.
02
Mechanism of action
Antibody-drug conjugate targeting DLL3, Bispecific T-cell engager targeting DLL3
03
Biological functions
Inhibition of Notch signalingRegulation of somitogenesisCell fate determination
04
Disease associations
Spondylocostal dysostosisSmall cell lung cancer (SCLC)Large-cell neuroendocrine carcinoma (LCNEC)Neuroendocrine prostate cancer
05
Safety considerations
Potential off-target effects due to low expression in normal adult tissues
06
Interacting drugs
Rovalpituzumab tesirine
1 more in the full profile.
07
Biomarkers
DLL3 expression level in tumors
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