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Target intelligence / Profile preview
Delta-like Ligand 4 (DLL4)
- Target
- DLL4
- Molecular classification
- Transmembrane protein, Notch ligand, Delta/Serrate/LAG-2 (DSL) family
01
Overview
Delta-like ligand 4 (DLL4) is a transmembrane protein and a ligand for Notch receptors, playing a critical role in vascular development, cardiac formation, and immune regulation. It functions as a negative regulator of angiogenic sprouting and is involved in macrophage activation, making it a potential therapeutic target for various cardiovascular, metabolic, and inflammatory disorders. Precise regulation of DLL4-Notch signaling is essential for normal development and tissue homeostasis.
- Other names
- Delta-like protein 4
02
Mechanism of action
Modulation of DLL4-Notch signaling
03
Biological functions
Negative regulator of vascular sproutingAngiogenesis controlMaintenance of second heart field progenitorsMacrophage activationNotch signaling pathway activation
04
Disease associations
AtherosclerosisVein graft diseaseVascular calcificationInsulin resistanceFatty liverIschemic retinopathyOutflow tract malformations
05
Safety considerations
Potential for developmental defectsUnintended effects on vascular homeostasisImmune-related adverse events
06
Interacting drugs
Anti-DLL4 antibodies
2 more in the full profile.
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