Target intelligence / Profile preview

Delta Like Non-Canonical Notch Ligand 1 (DLK1)

Target: DLK1
Molecular classification: Single-pass transmembrane protein, Notch/Delta/Serrate family, Growth factor

Overview

DLK1 encodes a transmembrane protein that regulates cell growth and differentiation, particularly adipogenesis. It exists in both membrane-bound and soluble forms, the latter generated by proteolytic cleavage. While it belongs to the Notch/Delta/Serrate family, it lacks the canonical DSL domain, suggesting non-canonical signaling mechanisms. DLK1 is implicated in cancer, where its overexpression is associated with poor prognosis and may mark cancer stem cells.

Other names: Protein delta homolog 1Pref-1FA1

Mechanism of action

ADAM17/TACE inhibition may indirectly affect DLK1 signaling, as it prevents the shedding of soluble DLK1.

Biological functions

Regulation of cell growthRegulation of cell differentiationInhibition of adipogenesisMaintenance of undifferentiated phenotype

Disease associations

CancerMetabolic diseases

Safety considerations

Modulating DLK1 may affect differentiation processes in various tissues.Paternally imprinted gene, potential risks associated with epigenetic therapies affecting imprinting

Biomarkers

DLK1 expression level as a prognostic marker in various cancersDLK1 expression level as a marker for cancer stem cells

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