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Target intelligence / Profile preview
Delta-like protein 1 (DLL1)
- Target
- DLL1
- Molecular classification
- Transmembrane ligand protein, Delta/Serrate/Jagged family, Notch ligand
01
Overview
Delta-like protein 1 (DLL1) is a transmembrane ligand protein that plays a critical role in the Notch signaling pathway, which is essential for cell fate determination during embryonic development and tissue homeostasis in adults. It acts as a ligand for NOTCH receptors, triggering proteolytic cleavage of the receptor and subsequent regulation of gene transcription. DLL1 is involved in various developmental processes, including somite formation, neural and immune system development. Dysregulation of DLL1 has been linked to neurodevelopmental disorders, holoprosencephaly, and neuroblastoma, making it an emerging therapeutic target.
02
Mechanism of action
miRNA therapy (targeting DLL1)
03
Biological functions
Cell lineage specificationDifferentiationProliferationPatterningMorphogenesisT-cell lineage commitmentMaintenance of adult stem cellsRegulation of neuronal differentiationLateral inhibition
04
Disease associations
Neurodevelopmental disorderSeptopreoptic holoprosencephalyNeuroblastoma
05
Biomarkers
MYCN amplification (in neuroblastoma)
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