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Delta-like Protein 1 Homolog
- Molecular classification
- Transmembrane protein, Ligand, NOTCH ligand, Growth factor
01
Overview
Delta-like protein 1 homolog refers to DLL1 (Delta-like canonical Notch ligand 1) and DLK1 (Delta-like non-canonical Notch ligand 1). Both are members of the delta/serrate/jagged family involved in Notch signaling. DLL1 is a canonical ligand that activates Notch receptors, influencing development, neurogenesis, and immune function. DLK1 is a non-canonical ligand that modulates Notch signaling, inhibiting adipogenesis and regulating muscle development. They are implicated in various diseases, making them potential therapeutic targets but require careful consideration due to their developmental roles.
- Other names
- DLL1Delta-like canonical Notch ligand 1DeltaDelta-Notch ligandDllDLK1Delta-like non-canonical Notch ligand 1FA1PREF-1Pref-1ZOGpG2Fetal antigen 1preadipocyte factor 1
02
Mechanism of action
DLL1: Activates Notch receptors. DLK1: Modulates/inhibits Notch receptors.
03
Biological functions
Notch signaling pathway modulationCell fate determinationSomite formationLeft-right asymmetry determinationNeurogenesisT-cell differentiationB-cell differentiationAdipogenesis inhibitionSkeletal muscle developmentPlacental formation
04
Disease associations
Neurodevelopmental disordersCongenital anomaliesAdipose tissue disordersMuscle developmental defects
05
Safety considerations
Potential for developmental defects if targeted during pregnancy.Complex effects on cell fate decisions could lead to unintended consequences in regenerative medicine or cancer therapy.
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