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Target intelligence / Profile preview
Delta-like ligand 4 protein (DLL4)
- Target
- DLL4
- Molecular classification
- Transmembrane protein, Ligand, Delta gene family
01
Overview
Delta-like ligand 4 (DLL4) is a transmembrane protein and a ligand for Notch receptors. It plays a critical role in angiogenesis by negatively regulating endothelial cell proliferation and migration. DLL4 is also involved in immune regulation, promoting proinflammatory phenotypes in immune cells. It has clinical relevance as a potential target for cancer therapy and cardiometabolic diseases.
- Other names
- DLL4Delta-like protein 4Delta4
02
Mechanism of action
Blockade of DLL4-Notch signaling, Inhibition of angiogenesis
03
Biological functions
Notch signaling pathwayAngiogenesis regulationCell-to-cell communicationRegulation of endothelial cell proliferation and migrationImmune regulationMacrophage activation
04
Disease associations
CancerCardiovascular diseasesInflammationAtherosclerosisInsulin resistance
05
Safety considerations
Potential side effects due to disruption of normal vasculature maintenanceExcessive angiogenic sprouting if inhibition is not carefully controlled
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