Delta-sarcoglycan (SGCD)

Delta-sarcoglycan is a transmembrane protein that is a critical subunit of the sarcoglycan complex, part of the larger dystrophin-associated glycoprotein complex (DGC) found in the membrane surrounding skeletal and cardiac muscle cells[1][3][4][7]. Delta-sarcoglycan, encoded by the SGCD gene, plays an essential role in maintaining the structural integrity of muscle tissue by linking the cytoskeleton to the extracellular matrix and stabilizing muscle fibers during contraction and relaxation[1][3][4]. Mutations in the SGCD gene cause limb-girdle muscular dystrophy type 2F (LGMD2F), a form of sarcoglycanopathy characterized by progressive muscle weakness—particularly of the pelvic and shoulder girdle—and in some cases, dilated cardiomyopathy[2][5][7]. Mutations typically disrupt the assembly or stability of the sarcoglycan complex, making muscle membranes more prone to damage[1][3][7]. Delta-sarcoglycan is not currently the direct target of any approved drugs, but it is a biomarker for genetic muscular dystrophy subtyping and disease monitoring[1][6].

Other names

Delta-SG35DAGDAGDLGMD2FCMD1L35 kDa dystrophin-associated glycoproteinLGMDR6SG-deltaSGCDPSGDdelta sarcoglycanplacental delta sarcoglycansarcoglycan, delta (35kDa dystrophin-associated glycoprotein)