Opioid Receptor Delta 1 (OPRD1)

OPRD1 encodes a G protein-coupled receptor that binds endogenous enkephalins and other opioids. It plays a key role in pain modulation, potentially influencing insulin secretion, and is implicated in diseases such as pain syndromes, irritable bowel syndrome, and metabolic disorders like type 2 diabetes. Selective activation or inhibition holds therapeutic potential, with careful consideration required for safety concerns like respiratory depression and seizure risk.

Other names

Delta-type opioid receptorDORDOPDOR-1D-OR-1

Upon ligand binding, activates G proteins, leading to inhibition of adenylate cyclase activity, decreased calcium ion currents, and increased potassium ion conductance.