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Target intelligence / Profile preview
Deltex E3 ubiquitin ligase 3L (DTX3L)
- Target
- DTX3L
- Molecular classification
- Enzyme, E3 ubiquitin ligase, RING-type ubiquitin ligase
01
Overview
DTX3L is an E3 ubiquitin ligase that plays crucial roles in DNA damage repair, antiviral responses, and signal transduction. It uniquely can ubiquitinate both protein substrates (including histones) and single-stranded nucleic acids. The protein forms important complexes with PARP9 and is over-expressed in chemotherapy-resistant lymphomas, making it a potential therapeutic target for cancer treatment.
- Other names
- E3 ubiquitin-protein ligase DTX3LBBAPRhysin2RNF143B-lymphoma- and BAL-associated proteinProtein deltex-3-likeRING-type E3 ubiquitin transferase DTX3LRhysin-2deltex 3 like E3 ubiquitin ligasedeltex 3-like
02
Mechanism of action
E3 ubiquitin ligase activity, Histone modification, Nucleic acid ubiquitination
03
Biological functions
Protein ubiquitinationDNA damage repairSignal transductionAntiviral responseImmune responseCell cycle regulation
04
Disease associations
CancerChemotherapy resistanceArteriovenous malformationsMicrocephalyInfection
05
Biomarkers
Over-expression in chemotherapy-resistant lymphomas
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