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Demethylmenaquinone Methyltransferase (MenG)
- Target
- MenG
- Molecular classification
- Enzyme, Methyltransferase
01
Overview
Demethylmenaquinone methyltransferase (MenG) is an enzyme that catalyzes the final step in the biosynthesis of menaquinone (vitamin K2) in bacteria. It transfers a methyl group from S-adenosyl-L-methionine (SAM) to demethylmenaquinone (DMK), producing menaquinone (MK). MenG is essential for bacterial respiration and energy production but is absent in humans, making it a promising target for antibacterial drug development.
- Other names
- S-adenosyl-L-methionine-DMK methyltransferaseDemethylmenaquinone C-methylase2-heptaprenyl-1,4-naphthoquinone methyltransferaseS-adenosyl-L-methionine:2-demethylmenaquinone methyltransferase
02
Mechanism of action
Inhibition of demethylmenaquinone methyltransferase activity, leading to impaired menaquinone biosynthesis and disruption of bacterial respiration.
03
Biological functions
Menaquinone biosynthesisVitamin K2 biosynthesisElectron transportOxidative phosphorylation
04
Disease associations
Infection
05
Safety considerations
Potential for off-target effects in gut microbiota.Development of bacterial resistance.
06
Interacting drugs
DG70
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