Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Demineralized dentin collagen and etched enamel hydroxyapatite serve as the fundamental substrates for modern adhesive dentistry. Enamel is primarily composed of hydroxyapatite crystals, which, upon acid etching, provide a high-energy surface with microporosities for micromechanical resin attachment (Pashley et al., 2011, Dental Materials). Dentin is a complex biological composite where acid conditioning removes the mineral phase to expose a scaffold of Type I collagen fibers (Breschi et al., 2008, Dental Materials). The therapeutic goal in restorative dentistry is the creation of a 'hybrid layer,' where adhesive resins encapsulate these collagen fibers to provide a durable seal against bacterial ingress and restore tooth function. However, this interface is susceptible to degradation by endogenous enzymes such as matrix metalloproteinases (MMPs) and cysteine cathepsins, which can be inhibited by agents like chlorhexidine to improve bond longevity (Tjäderhane et al., 2013, Dental Materials). Understanding the biochemical stability and mechanical properties of this target is crucial for developing long-lasting restorative materials and effectively treating dental caries (Liu et al., 2011, Journal of Dental Research).
Formation of a micromechanical bond via resin infiltration into microporosities of etched enamel and the exposed collagenous network of demineralized dentin to create a hybrid layer.
6 more in the full profile.
Beyond the preview
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Explore the programs pursuing this target and their development progress.
Follow the clinical studies evaluating therapies directed at this target.
Compare approaches across drug candidates, modalities, and indications.
Investigate the research and source evidence behind target biology and development.
Explore patent activity around therapies and technologies addressing this target.
Connect target biology, drug development, and emerging evidence in your research.
See how Gosset can support your research on Demineralized dentin collagen and etched enamel hydroxyapatite.