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Target intelligence / Profile preview
Dendrin (DDN)
- Target
- DDN
- Molecular classification
- Transcription factor, Other (nucleic acid-binding protein)
01
Overview
Dendrin is a DNA-binding transcription factor localized in both the cytoplasm and nucleus, most notably expressed in dendritic spines of neurons and in kidney podocyte foot processes[1][2][3][4][7]. It is implicated in positive regulation of transcription by RNA polymerase II and is known to promote apoptosis of glomerular podocytes, specialized kidney cells essential for the filtration barrier in urine formation[2][3][7]. Dendrin interacts with proteins such as nephrin, CD2AP, YAP1, and others, and has reported associations with several neurological, renal, and immune-related diseases[1][2]. Currently, dendrin is not recognized as a direct therapeutic target or drug receptor, and there are no drugs known to act directly on this protein.
- Other names
- DendrinDDNDenGm748KIAA0749
02
Mechanism of action
None established for drug action
03
Biological functions
Transcription regulation (positive regulation of transcription from RNA polymerase II promoter)Sequence-specific DNA bindingPromotes apoptosis of kidney glomerular podocytesProtein binding
04
Disease associations
Diabetic nephropathySchizophreniaBipolar disorderOsteoporosisSystemic lupus erythematosusMultidrug-resistant tuberculosisSpondyloepiphyseal dysplasia, Nishimura typePervasive developmental disorderExperimental crescentic glomerulonephritis
05
Safety considerations
No specific therapeutic safety concerns documented, as dendrin is not currently a therapeutic target
06
Biomarkers
Increase in dendrin-positive nuclei may serve as a marker in certain renal diseases such as IgA nephropathy
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