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Dendritic cell–T cell axis and T-lymphocyte subsets
- Molecular classification
- Other
01
Overview
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- Other names
- DC-T cell axisDendritic cell-T cell interactionT-lymphocyte subpopulationsImmune synapse
02
Mechanism of action
Modulation of the interaction between dendritic cells and T-lymphocytes through the targeting of co-stimulatory, co-inhibitory, and cytokine signaling pathways to regulate adaptive immunity [2, 4, 6].
03
Biological functions
Immune responseAntigen presentationT cell activationT cell differentiationImmune tolerance
04
Disease associations
CancerInflammationAutoimmune diseaseInfectionCardiovascular disease
05
Safety considerations
Immune-related adverse events (irAEs)Cytokine release syndromeAutoimmunityImmunosuppression
06
Interacting drugs
Abatacept
6 more in the full profile.
07
Biomarkers
CD4+ T cell countCD8+ T cell countCD80/CD86 expressionHLA-DR expressionIFN-gamma levels
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