Dendritic Cell Antigen Presentation Pathway (DC Antigen Presentation)

The dendritic cell antigen presentation pathway refers to the series of cellular and molecular events by which dendritic cells (DCs) capture, process, and present antigens to T lymphocytes. Dendritic cells are considered the most efficient antigen-presenting cells (APCs) in the immune system, playing a central role in initiating adaptive immune responses and establishing immunological tolerance. This pathway involves antigen uptake, processing into peptides, loading onto MHC molecules (MHC I and MHC II), and presentation to T cells, accompanied by co-stimulatory signals and cytokine secretion. Key processes include classical MHC II presentation to CD4+ T cells, and cross-presentation of exogenous antigens on MHC I to activate CD8+ T cells. Activation of DCs via PRRs like TLRs regulates the pathway, impacting immune responses in cancer, infection, and autoimmunity.

Other names

Dendritic cell-mediated antigen presentationAntigen presentation by dendritic cellsDC antigen processing and presentation

N/A - This is a pathway, not a single molecule.