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Dendritic Cell C-type Lectin Receptors (CLRs)
- Target
- CLRs
- Molecular classification
- Pattern Recognition Receptor, C-type Lectin Receptor
01
Overview
Dendritic cell C-type lectin receptors (CLRs) are a family of pattern recognition receptors (PRRs) predominantly expressed on dendritic cells (DCs), as well as other myeloid lineage cells. These receptors play a central role in the immune system by recognizing carbohydrate structures on pathogens and self-tissues, thereby linking innate and adaptive immunity. They mediate antigen uptake and presentation, and modulate immune responses. Depending on the ligand/receptor context, CLRs can promote pro-inflammatory responses against infections/cancer or induce immunosuppressive/tolerogenic outcomes.
- Other names
- C-type lectin receptorsDendritic cell CLRs
02
Mechanism of action
Modulation of dendritic cell activation and T cell polarization through glycan recognition and downstream signaling cascades (ITAM/ITIM)
03
Biological functions
Antigen UptakeAntigen PresentationImmune ModulationSignal TransductionCellular InteractionsInnate ImmunityAdaptive Immunity
04
Disease associations
InfectionCancerAutoimmune DisordersAllergiesMetabolic Diseases
05
Safety considerations
Potential for inducing immunosuppression or toleranceOff-target effects on other immune cells
06
Biomarkers
MICL/CLEC12A (AML marker)
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