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Target intelligence / Profile preview
Dendritic Cell-Mediated Antigen Presentation (Glioblastoma Stem-Like Cell Antigens) (DC-mediated Antigen Presentation (GSC Antigens))
- Target
- DC-mediated Antigen Presentation (GSC Antigens)
- Molecular classification
- Cellular process, Immunotherapy target
01
Overview
Dendritic cell-mediated antigen presentation is a crucial process for initiating adaptive immunity against glioblastoma, particularly by targeting glioblastoma stem-like cell (GSC) antigens. DCs acquire, process, and present these antigens on MHC molecules to activate T cells, promoting an anti-tumor immune response. Dendritic cell vaccines aim to enhance this process, but challenges include tumor-induced immunosuppression and the need for combination therapies to improve efficacy.
- Other names
- DC vaccinationDendritic cell immunotherapy for glioblastomaGlioblastoma stem cell antigen presentationDC-based cancer vaccines (GSC targets)
02
Mechanism of action
DCs process and present GSC-associated antigens on MHC molecules to activate T cells, leading to cytotoxic T lymphocyte-mediated tumor cell killing and helper T cell support.
03
Biological functions
Antigen processing and presentationT cell activationImmune responseAnti-tumor immunity
04
Disease associations
CancerGlioblastomaImmunosuppression
05
Safety considerations
Immune-related adverse eventsTumor-induced immunosuppressionLack of consistent overall survival benefit in clinical trialsDisease heterogeneity
06
Interacting drugs
Whole-tumor lysate
5 more in the full profile.
07
Biomarkers
HLA-DR/MHC-II expression on DCsCD86 expression on DCsPD-L1 expression on DCsAIM2 expression on tumor cellsMAGE-1 expression on tumor cellsHER2/neu expression on tumor cellsTRP2 expression on tumor cellsgp100 expression on tumor cellsIL13Rα2 expression on tumor cellsTumor-specific T cell responses
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