Dendritic cell receptors involved in Pru p 3 uptake and presentation

Dendritic cell receptors involved in Pru p 3 uptake and presentation represent a critical interface in the development of peach allergy and the broader lipid transfer protein (LTP) syndrome. Pru p 3, a small non-specific LTP, is internalized by dendritic cells through a receptor-mediated mechanism involving caveolae-dependent endocytosis rather than simple macropinocytosis. A defining feature of this target is the role of CD1d, which binds the phytosphingosine-based lipid ligand naturally associated with Pru p 3. This CD1d-lipid complex is presented to invariant natural killer T (iNKT) cells, providing the essential 'second signal' or adjuvant effect required to drive a Th2-biased allergic immune response. In addition to the native lipid-CD1d axis, researchers target C-type lectin receptors (CLRs) like the Mannose Receptor (CD206) and DC-SIGN (CD209) using synthetic glyco-conjugates of Pru p 3. These interactions are being explored for allergen-specific immunotherapy (AIT) to reprogram the immune system toward tolerance by inducing regulatory T cells. Understanding these receptors is vital for developing next-generation vaccines and diagnostic tools for severe food allergies, as they govern the initial sensitization and subsequent T-cell recognition of the allergen.

Other names

Pru p 3 receptorsCD1d (in the context of Pru p 3)MHC class II (in the context of Pru p 3)C-type lectin receptors (in the context of Pru p 3)Mannose receptor (CD206)DC-SIGN (CD209)

Blocking CD1d-mediated presentation of the Pru p 3 lipid ligand to iNKT cells; targeting C-type lectin receptors (CD206/CD209) with glycosylated allergen derivatives to induce tolerogenic dendritic cells and regulatory T-cell (Treg) responses.