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Target intelligence / Profile preview
Dendritic Cell-Specific Intercellular Adhesion Molecule-Grabbing Non-Integrin Receptor (DEC205)
- Target
- DEC205
- Molecular classification
- C-type lectin receptor, Type I transmembrane glycoprotein
01
Overview
DEC205 (CD205) is a type I transmembrane glycoprotein and a member of the C-type lectin receptor family. It is primarily recognized as an endocytic receptor highly expressed on dendritic cells (DCs), especially the CD8+ subset, as well as on cortical thymic epithelial cells, certain B cell populations, monocytes, and at lower levels on other immune cells such as NK and T lymphocytes. It mediates efficient endocytosis of antigens for presentation via MHC class I and II, recognizes apoptotic/necrotic cells, and binds CpG oligonucleotides, contributing to immune activation. Targeting antigens to DEC205 has been explored in vaccine development and cancer immunotherapy.
- Other names
- CD205
02
Mechanism of action
Targeting antigens to DEC205 via antibody-antigen fusion proteins to induce antigen-specific immune responses.
03
Biological functions
Antigen uptake & presentationCross-presentationEndocytosisRecognition of apoptotic/necrotic cellsCpG oligonucleotide bindingImmune response
04
Disease associations
CancerInfection
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