Dendritic Cell Surface Receptor

Dendritic cell (DC) surface receptors are a diverse group of membrane proteins expressed on dendritic cells, which are professional antigen-presenting cells central to the initiation and regulation of immune responses. These receptors play critical roles in pathogen recognition, antigen uptake and processing, cell migration, T-cell activation, and the induction of immune tolerance or immunity. Major classes include Pattern Recognition Receptors (PRRs) such as TLRs and CLRs, co-stimulatory molecules like CD80 and CD86, MHC molecules for antigen presentation, and chemokine receptors like CCR7. Targeting these receptors can modulate immune responses for vaccines, cancer immunotherapy, and autoimmune diseases.

Modulation of immune responses (activation or tolerance)