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Multiple Immune Cell Types (Analogous to Rabbit ATG) (N/A)
- Target
- N/A
- Molecular classification
- Cell Surface Antigens, MHC Molecules, Adhesion Molecules
01
Overview
The target "multiple immune cell types (analogous to rabbit ATG)" refers collectively to a range of surface-expressed proteins found on diverse leukocyte populations—including T-cells (CD2/CD3/CD4/CD8), B-cells, NK-cells, macrophages/dendritic cells—as well as MHC molecules. These are recognized by polyclonal rabbit-derived IgGs generated against human thymocytes or T-cell lines. This multi-target approach underlies the potent immunosuppressive effects observed with rabbit ATGs in clinical practice.
- Other names
- Rabbit Anti-Thymocyte Globulin TargetsT Cells (CD2, CD3, CD4, CD6, CD8)B CellsNatural Killer CellsMacrophagesDendritic CellsHLA Class I & II
02
Mechanism of action
Depletion of targeted lymphocyte populations via complement-dependent cytotoxicity and antibody-dependent cellular cytotoxicity. Modulation or downregulation of antigen expression.
03
Biological functions
Immune ResponseCellular AdhesionCell TraffickingInflammationApoptosisCell Proliferation
04
Disease associations
Transplant RejectionAutoimmune Diseases
05
Safety considerations
Infusion-related reactionsCytokine release syndromeInfectionsMalignancy
06
Interacting drugs
Rabbit ATG (Thymoglobulin, Grafalon)
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