Target intelligence / Profile preview

Dendritic cells expressing CD11b and CD11c (CD11b+CD11c+ DCs)

Target
CD11b+CD11c+ DCs
Molecular classification
Receptor (specifically integrins), Immune cell
01

Overview

Dendritic cells expressing CD11b and CD11c are a subset of immune cells that play a crucial role in bridging the innate and adaptive immune systems. They are involved in antigen uptake, processing, and presentation to T cells, thereby initiating immune responses. CD11c is a defining marker for dendritic cells, while CD11b is also expressed on certain subsets, contributing to their phagocytic and antigen-presenting capabilities. These cells are pivotal in inflammatory responses and can influence the development of various diseases, including cancer and autoimmune conditions.

Other names
CD11b+CD11c+ dendritic cellsCD11b and CD11c positive dendritic cells
02

Mechanism of action

Not applicable directly, but therapies targeting dendritic cell functions often involve modulating antigen presentation or immune activation pathways.

03

Biological functions

Immune responseAntigen presentationT-cell activation and proliferationPhagocytosisInflammation
04

Disease associations

CancerInflammationInfectionAutoimmune diseases
05

Safety considerations

Modulating dendritic cell functions can lead to immune-related adverse effects, such as excessive inflammation or autoimmunity.
06

Interacting drugs

Not specifically targeted by drugs, but therapies may modulate their function indirectly.
07

Biomarkers

CD11b and CD11c expression levels can serve as markers for dendritic cell subsets.

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