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Target intelligence / Profile preview
Dengue Virus Capsid Protein (C protein)
- Target
- C protein
- Molecular classification
- Structural protein, Viral protein
01
Overview
The dengue virus capsid protein is a structural protein essential for the assembly and infectivity of the dengue virus. Its primary function is to package and protect the viral RNA genome within new virions. It also exhibits chaperone activity, and interacts with host cell histones, potentially disrupting normal nucleosome formation and altering host gene expression during infection.
- Other names
- Dengue capsid proteinDENV capsid proteinCapsid protein
02
Biological functions
Viral genome packagingNucleocapsid formationRNA bindingHistone mimicryChaperone activityViral assembly
03
Disease associations
InfectionDengue feverFlavivirus infection
04
Safety considerations
Potential for off-target effects when targeting host-viral protein interactionsDrug resistance mutations
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