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Target intelligence / Profile preview
Dengue Virus Envelope Protein E
- Molecular classification
- Viral glycoprotein
01
Overview
The dengue virus envelope protein E is a membrane-spanning glycoprotein that plays a central role in the life cycle of the dengue virus. It is both the principal determinant of icosahedral virion assembly and acts as the fusion catalyst for merging viral and host cell membranes. The mature surface of each dengue virion is covered with 180 copies of this E protein arranged as homodimers. The E protein folds into three distinct domains: Domain I (ED1), Domain II (ED2), and Domain III (ED3). It mediates attachment to host cells and triggers fusion between viral and cellular membranes upon endosomal acidification. It is a major target for neutralizing antibodies.
02
Mechanism of action
Small-molecule inhibitors targeting the hydrophobic pocket at an interdomain interface.
03
Biological functions
Virion assemblyReceptor bindingpH-dependent membrane fusionViral entry
04
Disease associations
Infection
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