Target intelligence / Profile preview

Dengue Virus Membrane Protein (M protein)

Target: M protein
Molecular classification: Viral Structural Protein, Transmembrane protein, Ion channel

Overview

The dengue virus membrane (M) protein is a crucial structural protein involved in virion assembly, maturation, and infectivity. It is initially synthesized as prM and cleaved during maturation. M protein stabilizes the viral envelope structure and may play roles in membrane fusion. Recent research suggests M can form ion channels. Targeting prM/M processing is a potential antiviral strategy.

Other names: prM (pre-membrane protein)DENV M protein

Mechanism of action

Blocking virus assembly or egress steps via inhibition of prM/M cleavage and maturation.

Biological functions

Virion assemblyVirion maturationMembrane fusionIon transportProtection against premature fusion

Disease associations

InfectionDengue feverViral pathogenesis

Safety considerations

Off-target effects on host cell membranes due to structural similarities or ion channel activity interference.Potential for drug resistance development through mutations in the prM/M region.

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