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Target intelligence / Profile preview
Dengue Virus Serotype 2 (DENV-2)
- Target
- DENV-2
- Molecular classification
- Virus, Flavivirus
01
Overview
Dengue virus serotype 2 (DENV-2) is one of four antigenically distinct serotypes of the dengue virus, which belongs to the family Flaviviridae and genus Flavivirus. DENV-2 is a single-stranded, positive-sense RNA virus with a genome size of approximately 11 kilobases. The virus is primarily transmitted to humans through the bite of infected Aedes mosquitoes, especially Aedes aegypti. Infection with DENV-2 can result in mild dengue fever or severe dengue hemorrhagic fever/dengue shock syndrome. Secondary infection with DENV‑2 increases risk for these severe outcomes. The Cosmopolitan genotype is currently the most widespread globally.
- Other names
- Dengue 2 virusDENV2
02
Biological functions
Viral replicationHost cell entryImmune evasion
03
Disease associations
Dengue FeverDengue Hemorrhagic FeverDengue Shock SyndromeInfection
04
Safety considerations
Antibody-dependent enhancement (ADE) increases disease severity
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