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Target intelligence / Profile preview
Dengue Virus Serotype 3 (DENV-3)
- Target
- DENV-3
- Molecular classification
- Virus, RNA virus, Flavivirus
01
Overview
Dengue virus serotype 3 (DENV-3) is one of the four antigenically distinct serotypes of dengue virus, a member of the Flaviviridae family. DENV-3 is an enveloped, positive-sense single-stranded RNA virus transmitted primarily by Aedes mosquitoes. It is a major cause of dengue fever and severe forms such as dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS), particularly in tropical and subtropical regions. The genome encodes structural and nonstructural proteins crucial for viral replication and pathogenesis. No effective antivirals currently exist.
- Other names
- DENV3Dengue-3
02
Biological functions
Viral replicationInfectionImmune evasion
03
Disease associations
Dengue feverDengue hemorrhagic fever (DHF)Dengue shock syndrome (DSS)
04
Safety considerations
Antibody-dependent enhancement (ADE)Potential for severe disease manifestations (DHF/DSS)Lack of specific antiviral therapies
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