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Target intelligence / Profile preview
Dengue Virus Serotype 4 (DENV-4)
- Target
- DENV-4
- Molecular classification
- Virus, Flavivirus
01
Overview
Dengue virus serotype 4 (DENV-4) is one of four antigenically distinct serotypes of the dengue virus, a member of the Flaviviridae family. DENV-4 is an enveloped, single-stranded positive-sense RNA virus transmitted by Aedes mosquitoes. Infection with DENV-4 can cause classical dengue fever and, in some cases, severe dengue.
02
Biological functions
Viral replicationHost cell entryImmune evasionPathogenesis
03
Disease associations
Dengue feverDengue Hemorrhagic FeverDengue Shock SyndromeInfection
04
Safety considerations
Antibody-dependent enhancement (ADE) of infectionRisk of severe dengue upon secondary infection
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