Dengue virus serotype 4 envelope protein (DENV-4 E protein)

The Dengue virus serotype 4 envelope protein (E protein) is a structural glycoprotein on the viral surface, organized into three domains (EDI, EDII, EDIII) that form homodimers in a herringbone pattern on the mature virion. It mediates receptor binding, endocytosis, and low-pH-induced conformational changes for membrane fusion in host endosomes, with EDII exposing a fusion loop and hinge region critical for these processes. The protein is the primary target of neutralizing antibodies post-infection or vaccination, though domain-specific epitopes influence serotype cross-reactivity and antibody responses.[1][2][3][7][13]

Other names

DENV4 envelope glycoproteinDENV-4 E glycoproteinE protein