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Target intelligence / Profile preview
Dengue Virus Structural Antigens (DENV Structural Antigens)
- Target
- DENV Structural Antigens
- Molecular classification
- Viral Structural Protein, Glycoprotein
01
Overview
The structural antigens of Dengue virus (DENV) are proteins that form part of the mature virion particle. These include the Capsid protein (C), which encapsulates the viral RNA genome; the pre-membrane/Membrane protein (prM/M), involved in virion assembly and maturation; and the Envelope protein (E), the major surface glycoprotein responsible for receptor binding, membrane fusion, and eliciting neutralizing antibody responses. These proteins are the targets for neutralizing antibodies and play critical roles in viral entry and replication.
- Other names
- Dengue Virus Capsid ProteinDENV Capsid ProteinDengue Virus pre-membrane/Membrane ProteinDENV prM/M ProteinDengue Virus Envelope ProteinDENV E ProteinDENV C proteinDENV prM proteinDENV M proteinDENV E protein
02
Mechanism of action
N/A
03
Biological functions
Virion assemblyReceptor bindingMembrane fusionGenome protectionEliciting neutralizing antibody responsesImmune evasion
04
Disease associations
Dengue FeverDengue Hemorrhagic FeverDengue Shock SyndromeViral Infection
05
Safety considerations
Antibody-dependent enhancement (ADE)Serotype-specific immunityCross-reactive antibodies
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