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Target intelligence / Profile preview
Dengue Virus Type 1 (DENV-1)
- Target
- DENV-1
- Molecular classification
- Virus, Flavivirus, RNA virus
01
Overview
Dengue virus type 1 (DENV-1) is one of four serotypes of the dengue virus, a Flavivirus transmitted by Aedes mosquitoes. It is responsible for causing dengue fever, ranging from mild illness to severe hemorrhagic fever and shock. The virus contains a single-stranded RNA genome encoding structural (C, prM/M, E) and nonstructural (NS1, NS2A, NS2B, NS3, NS4A, NS4B, NS5) proteins. Infection induces serotype-specific immunity but can lead to antibody-dependent enhancement in subsequent infections with different serotypes, increasing the risk of severe disease. DENV-1 comprises several genotypes that circulate globally. Current treatments are mainly supportive, while antiviral and vaccine research is ongoing.
- Other names
- Dengue virus 1DENV1Dengue serotype 1
02
Mechanism of action
N/A - Current treatments primarily focus on symptom management and supportive care. Antiviral research is ongoing but not yet widely available.
03
Biological functions
Viral replicationHost cell entryImmune evasionInduction of viremiaModulation of host cell machinery
04
Disease associations
Dengue FeverDengue Hemorrhagic FeverDengue Shock SyndromeInfection
05
Safety considerations
Antibody-dependent enhancement (ADE) in secondary infectionsRisk of severe dengue (DHF/DSS)Vaccine development challenges due to ADE and serotype complexityPotential for neurological complications (rare)
06
Interacting drugs
Ribavirin (potential)
3 more in the full profile.
07
Biomarkers
Viral RNA detection (RT-PCR)NS1 antigen detectionIgG/IgM antibodiesPlatelet countHematocritLiver enzymes (ALT/AST)
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