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Target intelligence / Profile preview
Dengue Virus Type 2 (DENV-2)
- Target
- DENV-2
- Molecular classification
- Virus, Flavivirus
01
Overview
Dengue virus type 2 (DENV-2) is one of four serotypes of the dengue virus, a member of the Flaviviridae family. DENV-2 is a major cause of dengue fever and severe dengue, including dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). It is transmitted by Aedes mosquitoes, primarily Aedes aegypti. The viral genome encodes structural (C, prM, E) and nonstructural (NS1-NS5) proteins, with NS proteins representing therapeutic targets, particularly those involved in the RNA replication complex. Secondary infection with DENV-2 increases risk of severe disease due to mechanisms like antibody-dependent enhancement (ADE).
- Other names
- DENV2Dengue-2Dengue serotype 2
02
Mechanism of action
Inhibition of viral replication complex; inhibition of NS4B and its precursor intermediates
03
Biological functions
Viral replicationHost cell entryImmune evasionDisease induction
04
Disease associations
InfectionDengue FeverDengue Hemorrhagic FeverDengue Shock Syndrome
05
Safety considerations
Antibody-dependent enhancement (ADE) in secondary infectionsPotential for severe disease manifestations (DHF/DSS)
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