Dengue virus type 2 structural protein

Dengue virus type 2 structural proteins consist of three main components: the capsid protein (C), which encapsulates the viral RNA genome; the premembrane/membrane protein (prM/M), which assists in viral assembly and maturation; and the envelope protein (E), which forms the viral surface and mediates attachment to host cells and membrane fusion[1][2][3][4][5]. These proteins are translated from a single viral polyprotein and are critical for the viral life cycle, forming the core and entry machinery of the virion[4][5]. The E protein is a major target for neutralizing antibodies and vaccine development due to its external location and role in host interaction[3]. Structural variation, especially in E protein, underlies challenges for therapy and antibody recognition between dengue virus genotypes[3].

Other names

C proteinCapsid proteinEnvelope protein (E)Premembrane/membrane protein (prM/M)DEN2C

Neutralizing antibodies bind E protein to block viral attachment/fusion[3] (Experimental) Small molecules or peptides blocking assembly, envelope formation, or host receptor interaction (no approved drugs[2][3][4][5])