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Target intelligence / Profile preview
Dengue Virus Type 3 (DENV-3)
- Target
- DENV-3
- Molecular classification
- Virus, Flavivirus, RNA virus
01
Overview
Dengue virus type 3 (DENV-3) is one of four antigenically distinct serotypes of the dengue virus. It is a positive-sense single-stranded RNA virus transmitted by Aedes mosquitoes and causes dengue fever in humans. Infection with DENV-3 provides lifelong immunity to this serotype but not to others. Secondary infection by another serotype increases the risk of severe disease. Key proteins like NS3 protease/helicase and NS5 polymerase are potential drug targets. NS1 antigen is used for diagnostics.
- Other names
- DENV3Dengue virus 3Dengue serotype 3
02
Biological functions
Viral replicationHost cell entryImmune evasionPathogenesis
03
Disease associations
Dengue feverDengue hemorrhagic fever (DHF)Dengue shock syndrome (DSS)Infection
04
Safety considerations
Antibody-dependent enhancement (ADE) with secondary infection by different serotypeLack of specific antiviral treatmentEmergence of more virulent strains
05
Biomarkers
NS1 antigen
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