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Target intelligence / Profile preview
Dengue Virus Type 4 Envelope Protein (DENV-4 E protein)
- Target
- DENV-4 E protein
- Molecular classification
- Viral Structural Protein, Glycoprotein
01
Overview
The envelope (E) protein of dengue virus type 4 (DENV-4) is a structural glycoprotein located on the surface of the virion. It mediates receptor binding and membrane fusion, essential for infectivity and pathogenesis. The E protein is also a primary immunogen, eliciting neutralizing antibodies and a major target for vaccine development. It consists of three domains (EDI, EDII, EDIII), with EDIII being crucial for receptor binding and containing neutralizing epitopes. Glycosylation at Asn153 and Asn67 is important for DC-SIGN recognition. The E protein is a key component of dengue vaccine candidates.
- Other names
- DENV4 E proteinDengue 4 Envelope GlycoproteinDENV-4 Envelope Protein
02
Mechanism of action
Neutralization of viral entry through antibody binding
03
Biological functions
Receptor bindingMembrane fusionViral entryImmune response elicitation
04
Disease associations
Dengue feverViral infection
05
Safety considerations
Antibody-dependent enhancement (ADE)
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