Dengue virus type 4 structural protein (capsid protein, prM protein, envelope protein)

The **Dengue virus type 4 structural proteins** are composed of three distinct proteins—**capsid (C) protein**, **premembrane/membrane (prM/M) protein**, and **envelope (E) protein**, encoded by the viral genome as part of a single polyprotein. The **C protein** (∼12 kDa) forms homodimers and binds both viral RNA and lipid membranes, assembling the viral nucleocapsid[1][2][4]. The **prM/M protein** is essential for virion maturation, protecting E during assembly, and, upon cleavage, transitioning the immature virus to a mature, infectious state[3][6]. The **E protein** is the main surface glycoprotein responsible for attachment and entry into host cells, and contains domains for receptor binding, membrane fusion, and is the primary target of neutralizing antibodies[5]. Together, these proteins are essential for the formation, maturation, and infectivity of the virus and serve as key molecular targets for antiviral strategies and vaccine development[3][5][6].

Other names

Dengue virus type 4 C proteinDengue virus type 4 prM proteinDengue virus type 4 envelope proteinDENV4 structural proteinsDENV CprME

Monoclonal antibodies: neutralization of virus by binding to E protein and blocking attachment, fusion, or uncoating[5].