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Target intelligence / Profile preview
DENN domain-containing protein 11 (DENND11)
- Target
- DENND11
- Molecular classification
- Other (probable guanine nucleotide exchange factor or GEF)
01
Overview
DENN domain-containing protein 11 (DENND11) is a probable guanine nucleotide exchange factor (GEF), potentially involved in promoting the exchange of GDP to GTP, thereby activating small GTPase proteins[7][6][1]. It belongs to the DENND11 protein family, but its precise biological roles, interacting partners, and disease relevance remain poorly characterized[2][3][4]. DENND11 is expressed in various tissues, including the brain, but current data do not support its status as a therapeutic target, nor are there any approved or experimental drugs targeting this protein[3][6][7].
- Other names
- DENND11KIAA1147LCHNPRO2561protein LCHNDENN domain containing 11
02
Biological functions
Guanyl-nucleotide exchange factor activity (predicted/presumed, facilitating exchange of GDP to GTP on small GTPases)
03
Disease associations
Other (no well-characterized or established roles in major diseases as per current literature; further research may be needed)
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