DENN domain-containing protein 4C (DENND4C)

DENN domain-containing protein 4C (DENND4C) is a guanine nucleotide exchange factor (GEF) that activates the small GTPase Rab10 by facilitating the exchange of GDP for GTP, converting inactive GDP-bound Rab10 to its active GTP-bound form[1][2][4]. DENND4C plays a crucial role in insulin-regulated glucose uptake, particularly in adipocytes where it localizes to GLUT4 storage vesicles and enables their mobilization to the plasma membrane in response to insulin, thereby facilitating glucose transporter delivery to the cell surface[1][4]. It also interacts with the retromer complex involved in endosomal protein sorting, with dysfunction in these pathways linked to neurodegenerative diseases such as Parkinson’s and Alzheimer’s diseases[2][3]. DENND4C is part of the broader DENN domain family, a major subgroup of Rab GEFs, and is also implicated in metabolic homeostasis and potentially in a range of human disorders connected to vesicle trafficking and signal transduction[1][3][4].

Other names

RAB10GEFC9orf55C9orf55BbA513M16.3FLJ206861700065A05RikLOC100420355LOC102555797DENN domain containing 4C