DENN domain-containing protein 6B (DENND6B)

DENN domain-containing protein 6B (DENND6B) is a cytosolic guanine nucleotide exchange factor mainly for the small GTPase RAB14, and to a lesser extent RAB35[1][5][9]. It is involved in vesicle-mediated transport and endosomal trafficking, facilitating the exchange of GDP for GTP on Rab proteins that regulate membrane trafficking[1][5][7][8]. DENND6B is expressed in human tissues and is predicted to function in recycling endosomes, where it supports the regulation of intracellular membrane compartments and vesicle dynamics[1][8][9]. While its direct connection to human diseases is not well defined, DENND6B is important for normal vesicular trafficking physiology rather than being a druggable therapeutic target in current clinical contexts[1][7][8][9].

Other names

FAM116BMGC33692AFI1BDENND6BDENN/MADD domain containing 6BFamily with sequence similarity 116, member B

Drugs targeting this molecule—if future ones exist—would likely modulate guanine nucleotide exchange activity, specifically influencing Rab GTPase-regulated trafficking, but no such drugs are described