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Target intelligence / Profile preview
DENND1A antisense RNA 1 (DENND1A-AS1)
- Target
- DENND1A-AS1
- Molecular classification
- Non-coding RNA, lncRNA
01
Overview
DENND1A antisense RNA 1 (DENND1A-AS1) is a long non-coding RNA gene, transcribed antisense relative to the DENND1A gene. Unlike the protein-coding DENND1A (which is a guanine nucleotide exchange factor involved in endocytosis and associated with steroidogenesis and polycystic ovary syndrome), DENND1A-AS1 does not encode a protein and is not a known direct drug target. There is limited published information about the molecular or disease functions, interacting drugs, or biomarker utility for DENND1A-AS1. Most associations between DENND1A and disease (especially PCOS) relate to the coding DENND1A gene or its splice variants, not the antisense RNA transcript[1][2][3][5][7]. If you seek information on the well-studied *protein-coding* DENND1A gene (connecdenn 1), that is a distinct entity with specific roles in membrane trafficking and PCOS pathophysiology[1][2][3][7].
- Other names
- DENND1A-AS1DENND1A Antisense RNA 1
02
Biological functions
putative RNA-based regulatory roles; no specific biological functions are well characterized in the current literature
03
Disease associations
currently, the precise disease roles of DENND1A-AS1 are not established; PCOS associations involve the protein-coding DENND1A gene and its splice variants, not the antisense RNA
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