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DENND3 antisense RNA 1 (DENND3-AS1)

Target
DENND3-AS1
Molecular classification
Other, long non-coding RNA, lncRNA, antisense RNA
01

Overview

DENND3 antisense RNA 1 (DENND3-AS1) is a putative long non-coding RNA gene transcribed from the antisense strand of the DENND3 locus. Its symbol and name indicate it is likely to have a regulatory relationship with the sense gene DENND3, such as modulation of mRNA stability, splicing, or translation, but there is currently no published experimental data defining its molecular function, physiological role, disease associations, or suitability as a therapeutic target[4][5]. It is not considered a classical therapeutic target such as a receptor, enzyme, or transporter. If your goal is to map druggable therapeutic targets, DENND3-AS1 is not appropriate as it is not known to encode a protein or function as a direct drug target. Most available research and biological knowledge concern the protein-coding gene DENND3 rather than DENND3-AS1[7].

Other names
DENND3-AS1DENND3 AS1
02

Biological functions

Possible regulation of DENND3 gene expression (inferred from antisense orientation)
03

Disease associations

Unknown (no direct evidence of disease association or mechanism for DENND3-AS1; DENND3 protein is involved in intracellular trafficking and has possible links to cancer and Hirschsprung disease, but not via its antisense RNA)

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