Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Density regulated re-initiation and release factor (DENR)
- Target
- DENR
- Molecular classification
- Translation factor, RNA-binding protein
01
Overview
DENR is a protein involved in the regulation of translation re-initiation during protein synthesis. It forms a heterodimeric complex with MCTS1, which binds to the 40S ribosomal subunit and facilitates tRNA recruitment. Elevated DENR levels are observed in cancer and correlated with poor prognosis, suggesting it as a potential therapeutic target.
- Other names
- DRPDRP1SMAP-3density-regulated protein[3][8]
02
Mechanism of action
Modulation of translation re-initiation
03
Biological functions
Translation re-initiationmRNA turnover regulationRegulation of protein synthesis
04
Disease associations
CancerAutism spectrum disorderOptic nerve disease
05
Safety considerations
Potential for off-target effects due to ubiquitous expression
06
Biomarkers
DENR expression levels as prognostic marker in cancer
Beyond the preview
Go deeper on Density regulated re-initiation and release factor (DENR).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Density regulated re-initiation and release factor (DENR).