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Target intelligence / Profile preview
Dental Biofilm Microbial Composition (Dental Biofilm)
- Target
- Dental Biofilm
- Molecular classification
- Microbial Community, Polymicrobial Biofilm
01
Overview
Dental biofilm microbial composition refers to a dynamic polymicrobial community dominated by hundreds of bacterial taxa embedded within an EPS-rich extracellular matrix on tooth surfaces; its structure supports complex ecological interactions critical for both health maintenance and disease development in the oral cavity. The biofilm consists of early colonizers like Streptococcus spp., bridge species such as Fusobacterium nucleatum, and late colonizers like Porphyromonas gingivalis, all contributing to a complex and interactive ecosystem. Changes in the composition of dental biofilms are strongly associated with oral diseases.
- Other names
- Dental PlaqueOral BiofilmPlaque Biofilm
02
Mechanism of action
Disruption of biofilm formation, inhibition of bacterial growth, degradation of extracellular matrix, prevention of bacterial adhesion.
03
Biological functions
Microbial AdhesionCoaggregationMetabolic CooperationQuorum SensingHorizontal Gene TransferNutrient MetabolismExtracellular Matrix ProductionBiofilm FormationEcological Interactions
04
Disease associations
CariesPeriodontitisGingivitisOral Infections
05
Safety considerations
Development of antibiotic resistanceDisruption of oral microbiome balancePotential for opportunistic infectionsToxicity of antimicrobial agents to host cells
06
Interacting drugs
Antimicrobial Agents (e.g., Chlorhexidine, Triclosan)
3 more in the full profile.
07
Biomarkers
Specific bacterial species presence/abundance (e.g., Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans)pH levels within the biofilmExtracellular polysaccharide (EPS) levelsInflammatory markers in gingival crevicular fluid (e.g., MMPs, cytokines)
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