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Dental substrate adhesion" refers to the physical and chemical processes by which dental materials, such as adhesives or composites, bond to the surfaces of teeth—primarily enamel and dentin. This process is influenced by the surface energy of the substrate, the chemistry of the adhesive, and the interaction between the material and the tooth’s mineral and protein contents. Adhesion requires multiple steps, including etching (often with phosphoric acid), priming (using hydrophilic monomers to interact with the exposed collagen), and application of hydrophobic resin to create a stable, durable bond through micromechanical and chemical interactions. This concept is essential to restorative dentistry but does not refer to a discrete molecular entity or druggable target[1][3][4][7]. In summary, "Dental substrate adhesion" is not a target molecule or receptor, but a property or phenomenon important in dental restorative procedures.
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